Journal of Cytology & Histology

Sonia Abdelhak

Publications

• Research Article
  The Relationship between the Intercellular Adhesion Molecule-1 Expression and the Response to BCG Immunotherapy in Non Muscle Invasive Bladder Cancer
  Author(s): Faouzia Ajili, Sonia Abdelhak, Amel Nedri, Nadia Kourda, Afifa maaloul, Salma Karay, Mohamed Slim Salmi and Samir BoubakerFaouzia Ajili, Sonia Abdelhak, Amel Nedri, Nadia Kourda, Afifa maaloul, Salma Karay, Mohamed Slim Salmi and Samir Boubaker
  
  Background: Bladder cancer is the second most common malignancy of the urogenital region. Although Bacillus Calmette-Guerin (BCG) is considered as the adjuvant treatment of choice for non-muscle invasive bladder cancer (NMIBC), there is no consensus for a predictive factor to assess BCG success. The intercellular adhesion molecule-1 (ICAM1) has been reported to function in multiple malignancies, but its effect on NMIBC hasn't been discussed yet. This study attempted to evaluate if ICAM-1 could be useful predictive markers in BCG responses. Materials and Methods: Thirty primary resected NMIBC patients were included in the study. All patients received adjuvant BCG instillations. ICAM1 expression was inspected by immunohistochemistry and correlated with clinicopathologic variables. Association between protein expression and BCG therapy response w.. Read More»
  DOI: 10.4172/2157-7099.1000260

  Abstract PDF