Neurological Disorders

Sotirchos E

Publications

• Case Report
  An Unusual Case of Progressive Multifocal Leukoencephalopathy in a Patient with Non-traditional Risk Factors
  Author(s): Liebowitz JE, Zeiger W, Sotirchos E and Pardo-Villamizar CLiebowitz JE, Zeiger W, Sotirchos E and Pardo-Villamizar C
  
  Progressive multifocal leukoencephalopathy (PML) is a frequently fatal demyelinating condition of the central nervous system in which reactivation of the human polyomavirus JC (JCV) leads to lytic infection of oligodendrocytes. JCV reactivation typically occurs in the setting of profound impairment of cellular immunity seen in conditions such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), hematologic malignancies, autoimmune diseases, and treatment with immunosuppressive medications. However, an emerging body of literature suggests that minimal or occult immunosuppression may be sufficient for the development of PML in certain cases. We report the case of a 52 year old man diagnosed with PML without history of or risk factors for immunocompromise, with absolute number of CD4 + T cells below the lower limit of normal but not meeting criter.. Read More»
  DOI: 10.4172/2329-6895.1000247

  Abstract PDF