Nuclear Medicine & Radiation Therapy

Soumik Goswami

Publications

• Research Article
  Melatonin Pre-treatment Alleviates UVA Radiation Induced Oxidative Stress and Apoptosis in the Skin of a Diurnal Tropical Rodent Funambulus pennanti
  Author(s): Soumik Goswami and Chandana HaldarSoumik Goswami and Chandana Haldar
  
  UV radiation has been established as a pro-oxidant that mediates tissue injury by triggering the generation of free radicals. However UVA induced oxidative injury has never been investigated before in the skin of a tropical diurnal rodent which spends longer time directly under the sun for foraging. The present study aimed to note the level of oxidative stress induced by 6.36 Jcm-2 UVA radiations on the skin and its possible prevention by melatonin. The oxidative load was assessed by the activities of key antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) and generation of thiobarbituric acid reactive substances (TBARS). Cutaneous apoptosis if any was checked by the expression of Bcl-2, p53 and Heme oxygenase-I (HO-I). Melatonin membrane receptor expression (MT1) and AANAT activity was also investigated to elucidate the protective effe.. Read More»
  DOI: 10.4172/2155-9619.1000318

  Abstract PDF