Neurological Disorders

Souvik Sen

Publications

• Research Article
  Resting State Functional Connectivity and Thrombolysis Mediated Reperfusion in Acute Ischemic Stroke: A Pilot Study
  Author(s): Priyantha Herath, Taylor Hanayik, Kaitlin Krebs, Lauren Dennis, Christopher Rorden, Julius Fridriksson and Souvik SenPriyantha Herath, Taylor Hanayik, Kaitlin Krebs, Lauren Dennis, Christopher Rorden, Julius Fridriksson and Souvik Sen
  
  Introduction: Intravenous Tissue Plasminogen Activator (rTPA) is used to treat acute ischemic stroke (AIS). Early recanalization from this leads to better stroke outcomes, but the exact mechanism remains unknown. To clarify this, we correlated tissue perfusion and functional outcomes in acute stroke patients (AIS) who received rTPA to resting state default mode network (DMN) and task-positive (TPN) activities measured with fMRI. Following NIH stroke scale (NIHSS) assessments, patients underwent magnetic resonance imaging (MRI) scans during rTPA infusion (baseline), six hours post stroke and at 30d follow up visit. Results: Paired t-tests revealed that NIHSS at 6 hrs post stroke and at 30-days follow up significantly better compared to baseline, indicating improved functional outcomes. Changes in NIHSS were associated by significant changes in r.. Read More»
  DOI: 10.4172/2329-6895.1000221

  Abstract PDF