Helmholtz ZentrumMünchen, German Research Center for Environmental Health, Institute of Radiation Protection,
Ingolstädter Landstrasse 1, D-85764 Neuherberg
Germany
Review Article
Surface Acoustic Wave Actuated Lab-on-Chip System for Single Cell Analysis
Author(s): Stefan Thalhammer and Achim WixforthStefan Thalhammer and Achim Wixforth
The advent of multi-sensor microelectrodes for extracellular action potential recordings has significantly improved the quality of recorded signals, allowing more reliable detection and classification of action potentials recorded in vivo. These microelectrodes can also be used to localize neuronal signal sources, which may allow experimentalists to estimate other parameters including the neurons’ migration trends, intensities and sizes. This information can also be used to resolve neurons based on their location and type. However, as the exact characteristics of neurons are unknown during in vivo experiments, current attempts to localize neuronal signal sources have not been validated. This article presents experimental validation of a method capable of estimating both the location and intensity of an electrical source. To this end, a stimulating electrode was immersed in a sal.. Read More»
DOI:
10.4172/2155-6210.1000134
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