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Research Article
Bone Health in HIV-Infected Children, Adolescents and Young Adults: A Systematic Review
Author(s): Stephen M Arpadi, Stephanie Shiau, Charlotte Marx-Arpadi and Michael T YinStephen M Arpadi, Stephanie Shiau, Charlotte Marx-Arpadi and Michael T Yin
Background: Children and adolescent, who acquire HIV infection early in life either perinatally, from contaminated blood products or via sexual transmission, have the greatest cumulative exposure to the negative direct and indirect effects of HIV infection and ART on bone. This may lead to increased lifetime risk for osteoporosis and fracture. We conducted a systematic review to evaluate the literature on bone health in children and adolescents with HIV. Methods: We performed a comprehensive search of the Medline, Scopus, and Cochrane Library databases (up to April 1, 2014) for studies that reported on bone imaging or bone fractures in HIV-infected children, adolescents, or young adults. Results: A total of 32 publications met our inclusion criteria. Seventeen studies were cross-sectional and 15 were longitudinal. The majority of studies were conducted in high-income countries, three .. Read More»
DOI:
10.4172/2155-6113.1000374
Journal of AIDS & Clinical Research received 5264 citations as per Google Scholar report