Journal of Tissue Science and Engineering

Stephen W Sawyer

Publications

• Research Article
  Behavior of Encapsulated Saos-2 Cells within Gelatin Methacrylate Hydrogels
  Author(s): Stephen W Sawyer, Megan E Oest, Bryan S Margulies and Pranav SomanStephen W Sawyer, Megan E Oest, Bryan S Margulies and Pranav Soman
  
  The field of tissue engineering is still seeking a viable substitute to repair and replace damaged bone using a combination of porous implants, biochemical factors, and relevant cell types. While progress in this field has been made, current engineered solutions have not been able to mimic the architectural and biological requirements needed to provide a complete solution. In this work, bone-like human osteosarcoma cells were encapsulated inside gelatin methacrylate (GelMA) hydrogels of three different weight/volume (w/v) concentrations and stimulated to form mineral in order to determine the relationship between both bone formation and cellular activity with matrix stiffness. Distinct differences between cell morphology and mineral formation were found within the three types of hydrogels. Softer, less dense constructs were shown to provide a more cell friendly microenvironment that p.. Read More»
  DOI: 10.4172/2157-7552.1000173

  Abstract PDF