Journal of AIDS & Clinical Research

Steven E. Lipshultz

Publications

• Review Article
  The Effects of Fetal and Childhood Exposure to Antiretroviral Agents
  Author(s): Catherine M. Mas, Tracie L. Miller, Christina Cordero, Danielle Dauphin, Marie Boursiquot White, Christie K. Vila, Gabriel Somarriba, James D. Wilkinson and Steven E. LipshultzCatherine M. Mas, Tracie L. Miller, Christina Cordero, Danielle Dauphin, Marie Boursiquot White, Christie K. Vila, Gabriel Somarriba, James D. Wilkinson and Steven E. Lipshultz
  
  Purpose: The compliant use of combination antiretroviral therapy has virtually eliminated perinatal HIV transmission. Although antiretroviral drug toxicities in adults have been well documented, the effects of fetal and early childhood exposure to antiretroviral drugs on children of HIV-positive mothers are not well known. Methods: We searched the Pub Med database, reviewed publications, and selected abstracts on the use of antiretroviral agents to prevent HIV transmission and their effects on growth and cardiac endpoints in fetal and postnatal life. Results: The link between nucleoside analogs and mitochondrial dysfunction is controversial, and the association between in utero antiretroviral exposure and mitochondrial dysfunction in children is unclear. In utero exposure to antiretroviral therapy has effects on the heart, regardless of HIV status, including improved cardiac function .. Read More»
  DOI: 10.4172/2155-6113.S2-001

  Abstract PDF