Journal of Tissue Science and Engineering

Stig Larsen

Publications

• Research Article
  Using Human Cancer Cell Lines as In vitro Model for Testing the Efficacy of CDBPA; a New Anticancer Drug
  Author(s): Fuad Fares, Claus L. Jensen, Stig Larsen, Naiel Azzam, Basem Fares and Steen Lindkær-JensenFuad Fares, Claus L. Jensen, Stig Larsen, Naiel Azzam, Basem Fares and Steen Lindkær-Jensen
  
  The aim of the present study was to test the efficacy of cis-coordinated complexes of platinum (II) with the polymer of benzene-poly-carboxylic acids derived from lignin (CDBPA) (laboratory code BP-C1), an innovative anticancer compound, on the growth of several solid human cancer cell lines: bladder cancer, chondrosarcoma, colonic cancer, head and neck cancer, hepatic cancer, ovary cancer, pancreatic cancer and prostatic cancer. Furthermore, the effect of CDBPA on non-Hodgkin lymphoma cell lines was also tested. The effect of CDBPA on cell viability was detected by XTT assay and toxicity was detected by measuring the leakage of Lactate dehydrogenase from the cells to the media. The present study has demonstrated that CDBPA is not toxic and able to reduce cell viability substantially and significantly in various human cancer cell lines. When comparison of viability in percentage of th.. Read More»
  DOI: 10.4172/2157-7552.1000168

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