Medicinal Chemistry

Stig Larsen

Publications

• Research Article
  An Innovative Complex of Benzene-Poly-Carboxylic Acid and Molybdenum, for Prevention and Treatment of Radiation Dermatitis
  Author(s): Fuad Fares, Basem Fares, Naiel Azzam, Munir Nashashibi, Nevelsky Nevelsky, Stig Larsen and Steen Lindkær-JensenFuad Fares, Basem Fares, Naiel Azzam, Munir Nashashibi, Nevelsky Nevelsky, Stig Larsen and Steen Lindkær-Jensen
  
  Radiation dermatitis occurs in up to 95 percent of patients receiving radiotherapy. The aim of this study was to evaluate whether topical application of a new Benzene-Poly-Carboxylic Acid and Molybdenum Complex (BP-C2) prophylactically could protect mice skin from irradiation-induced dermatitis or treat irradiation-induced skin dermatitis, when it already has occurred. The right posterior leg of male BALB/cfC3H mice was exposed to radiation dose of 30 Gy. For prevention studies, animals were treated with BP-C2 just prior to irradiation and three times a week for 5 weeks post-radiation. For treatment studies, animals were treated with PB-C2 three times a week for five weeks when skin injury was appeared following irradiation exposure. Animals were sacrificed and skin damage was assessed using a non-linear semi-quantitative scale, as well as histologica.. Read More»
  DOI: 10.4172/2161-0444.1000299

  Abstract PDF