China
Research Article
Ginkgo Biloba Extract Protects Substantia Nigral Neurons from Apoptosis in PD Rat Model
Author(s): Cao Fei, Luo Fang, Zhang Lei, Su Ying, Chen Li, Hu Bo and Tong E-tangCao Fei, Luo Fang, Zhang Lei, Su Ying, Chen Li, Hu Bo and Tong E-tang
Purpose: To investigate the apoptotic mechanism during the pathological process of Parkinson disease (PD) and explore the availability of Ginkgo biloba extract (EGb) to cure PD.
Methods: Followed 6-OHDA injection stereotaxically to right side of substantia nigra pars compacta(SNc), at the date of 1, 7,14 and 21, we used biochemical, immunohistochemical, TUNEL and electron microscopic techniques to evaluate the level of apoptosis (TUNEL), monitor the degree of oxidative reaction (MDA.SOD), and to observe the change of ultrastructure of substantia nigra in the experimental PD models of rats (PD group), the EGb treatment group (EGb group) and the control group. Results: Contrast to the Control group, the number of apoptotic neurons and free radical level increased in the PD group and the EGb group, but the PD group surpassed th.. Read More»
DOI:
10.4172/2329-6895.1000118
Neurological Disorders received 1343 citations as per Google Scholar report