Journal of Computer Science & Systems Biology

Sudarshan Dhungana

Publications

• Research Article
  Simulation of Propagation of Action Potentials in Cardiac Tissue with an Inhomogeneous Distribution of Extracellular Potassium
  Author(s): Sudarshan Dhungana and Piyush KarSudarshan Dhungana and Piyush Kar
  
  We report simulation of experimental data for heterogeneous distribution of extracellular potassium, by developing and applying a mathematical model formulated by incorporating a Luo-Rudy representation of the cell membrane current into the bidomain model of the cardiac tissue. Our model serves to examine propagation of extra cellular potassium from a region of low potassium (normal) to a region of high potassium (ischemic). Starting with computer simulation of unipolar stimulation of cardiac tissue, we reproduced results of the passive bidomain model, and also simulated the space-clamped Luo Rudy model. Finally, we combined the Luo-Rudy model with the bidomain model. The diastolic threshold for anodal stimulation first decreased and then increased with increasing potassium concentration ([K]0), reaching a minimum value at [K]0=12mM. .. Read More»
  

  Abstract PDF