Journal of Bioanalysis & Biomedicine

Sudhanshu Kumar Bharti

Publications

• Research Article
  Essential Oil of Cymbopogon Citratus Against Diabetes: Validation by In vivo Experiments and Computational Studies
  Author(s): Sudhanshu Kumar Bharti, Amit Kumar, Om Prakash, Supriya Krishnan and Ashok Kumar GuptaSudhanshu Kumar Bharti, Amit Kumar, Om Prakash, Supriya Krishnan and Ashok Kumar Gupta
  
  This study evaluates the antidiabetic activities of essential oil obtained by steam distillation of the leaf sheath of Cymbopogon citratus (CCEO) in poloxamer-407 induced type 2 diabetic (T2D) Wistar rats. The sample was then analyzed by gas chromatography-mass spectroscopy (GCMS) identifying 23 compounds representing 96.9% of the oil. The major compounds of essential oil were geranial (42.4%), neral (29.8%), myrcene (8.9%) and geraniol (8.5%). When compared to diabetic control rats, the CCEO treated diabetic rats presented significant amelioration of glycaemia, insulinamia and lipid dysmetabolism, accompanied by increased GLP-1 content in cecum and remarkable reduction of oxidative markers. Histopatholgical analysis of pancreas showed increase in β-cell mass, islet number and quality of insulitis. HYBRID and FRED docking were performed for 48 documented CCEO phytoconstituents fo.. Read More»
  DOI: 10.4172/1948-593X.1000098

  Abstract PDF