College of Veterinary Science,
Tirupati-517502, Andhra Pradesh
India
Research Article
Nucleolar Organizer Region Count, PCNA and Ki-67 Indices are Diagnostic Markers of Malignancy and Cell Proliferation Rate in Bovine Lymphosarcoma
Author(s): Shruthi PJ, Sujatha K, Srilatha CH and Chengalva Rayulu VShruthi PJ, Sujatha K, Srilatha CH and Chengalva Rayulu V
Lymphoid tumors comprise one of the most common groups of tumors in domestic animals. Lymphosarcoma is expressed as a specific multicentric form in calvesupto six months of age (sporadic) and in adult cattle (enzootic); and as thymic form in young cattle. Eight calves of both sexes aged below six months were necropsied in the department of veterinary Pathology, college of Veterinary Science, Tirupati. During necropsy impression smears, represented tissue samples were collected for Cytopathology, histopathology, AgNOR count and immunohistochemical studies. Cytological smears revealed lymphocytes, prolymphocytes and lymphoblasts with anaplastic changes. Histopathologically, partial to complete obliteration of architecture due to the replacement of normal tissue by lymphoblastic cells in lymphnodes and other visceral organs. The mean AgNOR count of the lymphosarcoma was 4.25 and it appea.. Read More»
DOI:
10.4172/2157-7579.1000305
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