India
Research Article
Salutary Effects of Germinated Glycine max Seeds on Post Prandial Hyperglycemia and Dyslipidemia - Evidence from In-vivo and In-vitro Studies
Author(s): Richa Gupta, Suman Bala Sharma and Usha Rani SinghRicha Gupta, Suman Bala Sharma and Usha Rani Singh
Background: Germinated Glycine max seeds have been known to have anti-hyperglycemic effects; however, a comprehensive study pertaining to this has never been experimentally determined.
Methods: The aqueous extract of 12 h germinated Glycine max seeds (gGmax) were orally administered to Streptozotocin induced diabetic rats for 28 days and the effects were observed on glycemic index, lipid profile, antioxidant parameters alpha amylase and alpha glucosidase activity. Further the histomorphological changes were seen in the rat’s pancreas. Finally, the metabolite profiling was done.
Results: There was a significant improvement in FBG and OGTT in diabetic rats treated with gGmax after a period of 28 days. The extract also led to a substantial increase in the levels of insulin and c-peptide as compared to diabetic control rats with marked improveme.. Read More»
DOI:
10.4172/2327-5162.1000237
Alternative & Integrative Medicine received 476 citations as per Google Scholar report