Alternative & Integrative Medicine

Suman Bala Sharma

Publications

• Research Article
  Regulation of Gene Expression in Downstream Signaling Molecules by Herbal Compound in Insulin Resistant Diabetic Rats
  Author(s): Aiman Abbas Jafri, Suman Bala Sharma, Kalpana Luthra, Mohit Mehndiratta, Nikhil Khurana and Usha Rani SinghAiman Abbas Jafri, Suman Bala Sharma, Kalpana Luthra, Mohit Mehndiratta, Nikhil Khurana and Usha Rani Singh
  
  Background: In previous studies, Sharma et al. has already isolated an anti-hyperglycemic compound from the fruit pulp of Eugenia jambolana using HPLC and other chromatographic techniques. However, the effect of antihyperglycemic compound (FIIc) on the expression of PPAR gamma, IRS-1 and IRS-2 in high sucrose diet induced type 2 diabetic rats has not been studied so far. Methods: There were exactly 24 Male Wistar rats were taken and fed on High Sucrose Diet (HSD) for the development of type 2 diabetic animal for 30 weeks. Active compound FIIc was given to group C and Pioglitazone to group D at dose of 20 mg/kg of b.w. orally for 30 weeks respectively. Blood was drawn for the estimation of plasma glucose and serum insulin at week o and at week 30 from retro orbital plexus. At the end of the study animal were sacrificed and organs including panc.. Read More»
  DOI: 10.4172/2327-5162.1000243

  Abstract PDF