Cancer Science & Therapy

Sunita N Dyavanagoudar

Publications

• Review Article
  Oral Submucous Fibrosis: Review on Etiopathogenesis
  Author(s): Sunita N DyavanagoudarSunita N Dyavanagoudar
  
  Summary data from recent epidemiological studies provide overwhelming evidence that areca nut is the main aetiological factor for OSF. Commercially freeze dried products such as pan masala, Guthka and mawa have high concentrates of areca nut per chew and appear to cause OSF more rapidly than by self prepared conventional betel quid that contain smaller amounts of areca nut. It is logical to hypothesize that the increased collagen synthesis or reduced collagen degradation as possible mechanisms in the development of the disease. These chemicals appear to interfere with the molecular processes of deposition and/or degradation of extracellular matrix molecules such as collagen. In vitro studies on human fibroblasts using areca extracts or chemically purified arecoline support the theory of fibroblastic proliferation and increased collagen formation that is also demonstrable histologicall.. Read More»
  

  Abstract PDF