Journal of Cytology & Histology

Sunny Shen

Publications

• Research Article
  Orbital IgG4 Related Disease (IgG4RD): Incidence and Accompanying Histological Features Using the Latest Consensus Criteria
  Author(s): Anita SY Chan, Sunny Shen, Audrey Looi Lee Geok, Seah Lay Leng, Leonard Tan Hwan Cheong and Issam Al JajehAnita SY Chan, Sunny Shen, Audrey Looi Lee Geok, Seah Lay Leng, Leonard Tan Hwan Cheong and Issam Al Jajeh
  
  Purpose: Orbital Immunoglobulin 4 (IgG4) related disease (IgG4RD) is a fibro-inflammatory condition that mimics sclerosing orbital inflammatory disease (OID). The recently published IgG4RD consensus criteria included its defining histological features. Using the published criteria, this study aims to describe the frequency of orbital IgG4RD and its histological features in OID biopsies over a 1 year period. Method: Thirty-seven consecutive orbital biopsies for OID over 1 year were prospectively examined for the features of fibrosis, inflammation, and vasculitis. Immunohistochemistry (IHC) evaluation was performed when significant fibrosis and/or lymphoplasmacytic inflammation ( >25% of the biopsy section) was present. Results: Ten of 37 (27%) orbital biopsies showed significant fibrosis and/ or lymphoplasmacytic inf.. Read More»
  DOI: 10.4172/2157-7099.1000286

  Abstract PDF