Immunochemistry & Immunopathology

Suresh G Joshi

Publications

• Review Article
  Autoimmune Diseases of the Innate and Adaptive Immune System including Atopic Dermatitis, Psoriasis, Chronic Arthritis, Lyme Disease, and Alzheimers Disease
  Author(s): Herbert B Allen, Christine M Shaver, Chloe A Etzler and Suresh G JoshiHerbert B Allen, Christine M Shaver, Chloe A Etzler and Suresh G Joshi
  
  In atopic dermatitis, we have recently shown the innate immune system is activated by biofilm-forming staphylococci that occlude sweat ducts. Toll-like receptor 2 (TLR 2) is activated and moves from its epidermal control location in the basal zone to the proximal stratum corneum (surrounding the occluded duct). There it likely initiates the MyD88 and the PAR 2 pathways in an effort to inactivate the staphylococci; these efforts are fruitless because of the biofilms and lead to the prime pathological finding of spongiosis and to the prime symptom of pruritus which leads to the disease. If the pruritus is intense enough to cause excoriations severe enough to disrupt the epidermis, the involvement of the dermis likely causes the activation of the adaptive immune system leading to the documented appearance of IL 31, another even more potent pruritogen. .. Read More»
  DOI: 10.4172/2469-9756.1000112

  Abstract PDF