Japan
Research Article
Preoperative Cervical Cytology and E-Cadherin Expression in Endometrial
Cancer
Author(s): Osogami H, Tanaka R, Suzuki T, Tamate M, Habata S, Sugio A, Matsuura M, Iwasaki M and Saito TOsogami H, Tanaka R, Suzuki T, Tamate M, Habata S, Sugio A, Matsuura M, Iwasaki M and Saito T
Objective: It is reported that cervical cytology is a significant factor related to stage, tumor grade, nodal metastasis, recurrence and survival rate in endometrial cancer. Moreover, reduced expression of the cell adhesion molecule E-cadherin is associated with higher tumor grade and metastasis in endometrial cancer. The objective of this study is to evaluate the relationship between the results of cytological assessment of glandular cells in cervical cytology before surgery, prognostic factors, and E-cadherin expression in endometrial cancer. Methods: Between 2004 and 2011, 263 patients with endometrial cancer at all stages were treated with hysterectomy. We reviewed preoperative cervical smears and assigned each to one of three categories: (1) Negative, (2) Atypical glandular cells (AGC), and (3) Adenocarcinoma (AC). The relationship of these cytology, prognostic factors, and E-cad.. Read More»
DOI:
10.4172/2157-7099.1000386
Journal of Cytology & Histology received 2476 citations as per Google Scholar report