Professor & Head Biochemistry Section,
Peshawar, KPK
Pakistan
Research Article
Synthesis, Characterization, Biodistribution and Scintigraphic Evaluation of Technetium-99m (99mTc) Labeled Pazufloxacin (PZN): A Novel Infection Radiotracer
Author(s): Syed Qaiser Shah and Shahia KhattakSyed Qaiser Shah and Shahia Khattak
In this study tagging of 99mTc with PZN was examined with regards to different concentration of PZN, stannous chloride, 99mTc and pH ranges from 5.00-6.00. The suitability of the 99mTc labeled PZN was assessed in terms of percent radiochemical purity (%RCP) yield in normal saline at concentration value of the stannous chloride as 120 mg, stability in serum (in vitro) at 37°C at different intervals, in vitro up take by live and heat killed E. coli, biodistribution behavior in artificially E. coli (live and heat killed) infected animal model rat and scintigraphic accuracy in artificially E. coli infected animal model rabbit. Maximum %RCP yields of 98.25 ± 0.26% was observed after 30 m of labeling using 2 mg of PZN, 125 μg stannous chloride, 2.5 m Ci sodium pertechnetate and pH 5.3. The labeled PZN showed stable profile in serum at 37°C with a total decay of 16.40 &plus.. Read More»
DOI:
10.4172/2155-9619.S8-004
Nuclear Medicine & Radiation Therapy received 706 citations as per Google Scholar report
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