Journal of Bioanalysis & Biomedicine

Sylviane Lesieur

Publications

• Research Article
  Systemic Magnetic Targeting of Pure-Antiestrogen-Loaded Superparamagnetic Nanovesicles for Effective Therapy of Hormone- Dependent Breast Cancers
  Author(s): Vincent Plassat, Jack-Michel Renoir, Gwennhael Autret, Véronique Marsaud, Christine Ménager, Olivier Clément and Sylviane LesieurVincent Plassat, Jack-Michel Renoir, Gwennhael Autret, Véronique Marsaud, Christine Ménager, Olivier Clément and Sylviane Lesieur
  
  Systemic hormone therapy of breast cancer often suffers from severe side effects mainly due to non-specific drug delivery. To overcome this limitation, we propose an effective strategy based on the association of the selective estrogen receptor down-regulator RU-58668 (RU) that acts as a pure hormone antagonist, with magnetic-fluidloaded liposomes (MFLs) which can be driven selectively into the tumors by a magnetic field gradient. MFLs consisted in 200-nm unilamellar phospholipid vesicles entrapping superparamagnetic iron oxide nanocrystals, fluorescently labeled and coated by poly(ethylene glycol) (PEG) chains ensuring long plasmatic half-life. Significant antitumoral activity of antiestrogen at doses usually sub-therapeutic was demonstrated against MCF-7 tumors xenografts in nude mice after weekly intravenous administration of RU-loaded MFLs followed by 4-hour exposure to an .. Read More»
  DOI: 10.4172/1948-593X.1000077

  Abstract PDF