Molecular Biomarkers & Diagnosis

Tabone Marie- Dominique

Publications

• Research Article
  Molecular Reclassification in Pediatric Osteosarcomas at Surgical Resection is a Potential Helpful Prognostic Marker
  Author(s): Lasthaus Christelle, Litzler Marie, Marcellin Luc, Chenard Marie- Pierre, Marec-Berard Perrine, Tabone Marie- Dominique, Pacquement Hélène, Brugières Laurence, Guenot Dominique and Entz-Werlé NatachaLasthaus Christelle, Litzler Marie, Marcellin Luc, Chenard Marie- Pierre, Marec-Berard Perrine, Tabone Marie- Dominique, Pacquement Hélène, Brugières Laurence, Guenot Dominique and Entz-Werlé Natacha
  
  Introduction: The management of pediatric high grade osteosarcoma is lacking new approaches to classify closely the patients and adapt thereafter the treatment initially or post-operatively. The objective of this study was to estimate the impact of the tumor molecular response comparatively to initial biopsy and to see if this molecular analysis was correlated to the histological response to neoadjuvant chemotherapy and/or prognosis. Material and methods: 33 patients were included and allelotyping analyses using 23 micro satellites were performed on biopsy’s and tumor’s DNA versus normal blood DNA. Allelic imbalances were detected in all biopsy samples and the number of persistent AIs or not were quantified on tumors after pre-operative chemotherapy. Results: We identified 4 subgroups with a significant.. Read More»
  DOI: 10.4172/2155-9929.1000229

  Abstract PDF