Molecular Biomarkers & Diagnosis

Tadayasu Togawa

Publications

• Research Article
  Determination of Trace Metals in Human Seminal Plasma Using Inductively Coupled Plasma Mass Spectrometry and Multivariate Statistical Analyses for Sperm Parameters
  Author(s): Masatoki Katayama, Satoru Kaneko, Kiyoshi Takamatsu, Takahiro Tsukimura and Tadayasu TogawaMasatoki Katayama, Satoru Kaneko, Kiyoshi Takamatsu, Takahiro Tsukimura and Tadayasu Togawa
  
  We have simultaneously determined the presence of 30 different trace metals in human seminal plasma by Inductively Coupled Plasma Mass Spectrometry (ICP−MS). To date, high concentrations of metals (e.g. Zn, Cu, Mg and Fe) in seminal plasma have been sporadically reported and only few reports have discussed the relationships between trace metals and human semen profiles. Ninety-four seminal plasma specimens were first classified in three groups (normozoospermia, oligozoospermia, and azoospermia) according to the WHO guideline for sperm concentration. No significant differences were found among the three groups for all the metals examined. The concentration of metals in the specimens were then compared with sperm concentration, motility, morphology, and volume using multivariate regression analysis, principal component analysis (PCA) and cluster analysis. The most cumulative contr.. Read More»
  DOI: 10.4172/2155-9929.1000147

  Abstract PDF