Journal of Cytology & Histology

Taha HA

Publications

• Research Article
  Study of the Effect of Aristolochic Acid on Mice Kidney and the Effect of Withdrawal: Histological and Immunohistochemical Study
  Author(s): Ali Hamouda AH, Taha HA and Ahmad RFAli Hamouda AH, Taha HA and Ahmad RF
  
  Aristolochic acid (AA), one of the commonly used herbal medicines was reported to cause harmful effect on kidney. In this work, we aimed to study the effect of AA on renal tissue and to investigate the effect of its withdrawal. Methods: Forty five adult male mice were randomly assigned to three groups. Control group, Group 1 where mices were treated with aristolochic acid (AA) i.p. in a dose of 3 mg/kg every 3 days for 6 weeks. In group 2 the (remodeling group), AA was administered i.p. in a dose of 3 mg/kg every 3 days for 6 weeks, followed by 6 weeks remodeling (withdrawal) time. Urine and blood samples were collected; creatinine, BUN and P/C ratio were estimated. Renal specimens were processed for histological examination by H&E, Masson trichrome and immunohistochemical stain for PCNA. Results: in group 1 treated with AA, histological examination revealed that some tubules were.. Read More»
  DOI: 10.4172/2157-7099.1000504

  Abstract PDF