Journal of Clinical Case Reports

Taichi Kitaoka

Publications

• Case Report
  Report of Two Dental Patients Diagnosed with Hypophosphatasia
  Author(s): Rena Okawa, Taichi Kitaoka, Kanae Saga, Keiich Ozono and Kazuhiko NakanoRena Okawa, Taichi Kitaoka, Kanae Saga, Keiich Ozono and Kazuhiko Nakano
  
  Hypophosphatasia is a rare inherited skeletal disorder characterized by defective bone mineralization and tissue non-specific alkaline phosphatase (TNSALP) deficiency, with mutations in the gene encoding the TNSALP isozyme the cause. As for dental manifestations, premature loss of primary teeth due to disturbed cementum formation is well known and tooth roots in affected patients are not able to adequately attach to absorbed alveolar bone due to malformed cementum. We report spontaneous early exfoliation along with mild to severe mobility of primary anterior teeth in 2 child patients referred to pediatric dentists from a general dental practitioner. Case 1 was a 1-year-7- month-old boy with 3 mandibular incisors exfoliated, while Case 2 was a 3-year-3-month-old girl with 1 mandibular central incisor exfoliated. The possibility of hypophosphatasia was considered and the patients were r.. Read More»
  DOI: 10.4172/2165-7920.1000704

  Abstract PDF