Journal of Hypertension: Open Access

Takahiro Ueno

Publications

• Research Article
  Olmesartan Improves the Formation of Impaired Epcs and Renal Degeneration through Activation of the ACE2/Ang-(1–7)/Mas Receptor Axis in Shrs
  Author(s): Noboru Fukuda, Naohiko Kobayashi, Akihiko Nagase, Ryo Suzuki, Takahiro Ueno and Toshihiko IshimitsuNoboru Fukuda, Naohiko Kobayashi, Akihiko Nagase, Ryo Suzuki, Takahiro Ueno and Toshihiko Ishimitsu
  
  Objective: We investigated the effects of angiotensin II (Ang II) type 1 (AT1) receptor blocker (ARB) olmesartan on impaired endothelial progenitor cells (EPCs) and renal degeneration through angiotensin converting enzyme 2 (ACE2)/ Ang-(1–7)/Mas receptor (MasR) axis in salt-loaded spontaneously hypertensive rats (SHRs). Methods: Wistar-Kyoto/Izm (WKY) rats and SHR/Izm were salt-loaded. SHRs were treated with vehicle, hydralazine, olmesartan, and olmesartan plus MasR antagonist A779 for 2 weeks. Peripheral blood mononuclear cells were isolated and subjected to flow cytometric analysis to determine the number of circulating EPCs. To evaluate the mechanisms of effects of olmesartan on renal degeneration, we investigated morphological changes and expression of ACE1, ACE2, MasR, VEGF, eNOS, NAD(P)H oxidases, HIF-1α, CTGF and TGF-&beta.. Read More»
  DOI: 10.4172/2167-1095.1000138

  Abstract PDF