Journal of Cytology & Histology

Takaki Sakurai

Publications

• Research Article
  Investigation of the Possible Cytopathological Effect of Human Papillomavirus Infection on p-16INK4a Overexpressed Urothelial Carcinomas of the Bladder in the Urine
  Author(s): Seiko Ogura, Toshitetsu Hayashi, Keiko Yano, Masami Sakurai, Takaki Sakurai and Reiji HabaSeiko Ogura, Toshitetsu Hayashi, Keiko Yano, Masami Sakurai, Takaki Sakurai and Reiji Haba
  
  Background and objectives: Human papillomavirus (HPV) is well-known as the etiological agent for uterine cervical cancer or carcinoma of the oropharynx, anus and vulva. However, the cytopathologic effect of the HPV infection in urinary bladder tumors has rarely been reported. The present study has been carried out to search for cytopathologic differences between HPV positive and negative cases with urothelial carcinoma. Methods: We examined 91 specimens from 63 patients who underwent transurethral resection or biopsy for papillary urothelial carcinomas between May 2010 and September 2012. p-16INK4a expression was evaluated by immunohistochemistry. Detection of HPV DNA was carried out by in situ hybridization on formalin-fixed, paraffinembedded tissue sections. Urine smears were compared cytomorphologically between HPV-positive and HPVnegative .. Read More»
  DOI: 10.4172/2157-7099.1000335

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