Journal of Bioengineering & Biomedical Science

Takashi Kuroiwa

Publications

• Research Article
  Preparation of Lipid Vesicles Having Suitable Size for Drug Delivery with High Entrapment of Hydrophilic Molecules Using Multiple Emulsions
  Author(s): Sosaku Ichikawa, Yuya O, Seigo S, Emmanuel CO, Takashi Kuroiwa, Yasuyuki M, Takeshi W and Takeshi ISosaku Ichikawa, Yuya O, Seigo S, Emmanuel CO, Takashi Kuroiwa, Yasuyuki M, Takeshi W and Takeshi I
  
  A method for preparing lipid vesicles having suitable size for drug delivery (in a few hundred nanometer size) with high entrapment efficiency of hydrophilic molecules was developed. The lipid vesicles containing hydrophilic molecules in their internal compartments were formed from water-in-oil-in-water (W1/O/W2) multiple emulsions after the removal of organic solvent by evaporation under ambient condition. The primary W1/O emulsions were formed via homogenization by sonication of mixture of oil phase containing bilayer forming lipids, and the water phase containing hydrophilic molecules to be entrapped. The W1/O/W2 multiple emulsions were formed through microchannel (MC) emulsification by introducing the dispersed phase, i.e., (W1/O) emulsion, into the MC device in the presence of polymeric surfactants in the external water phase. The average size of the lipid vesicles formed, measur.. Read More»
  DOI: 10.4172/2155-9538.1000213

  Abstract PDF