Journal of Bioanalysis & Biomedicine

Tangning Xie

Publications

• Research Article
  The Bioavaliability of Hepatoprotective Flavoniods in Hypericum Japonicum Extract
  Author(s): Ning Wang, Yonggang Wang, Peibo Li, Wei Peng, Tangning Xie, Yibin Feng and Weiwei SuNing Wang, Yonggang Wang, Peibo Li, Wei Peng, Tangning Xie, Yibin Feng and Weiwei Su
  
  Purpose: To study the absorption of main flavonoids in Hypericum japonicum extract (HJE) with liver protective property; Method: HPLC-ESI-MS was introduced to identify and evaluate the flavonoids in HJE; Caco-2 cell monolayer model was established and validated, and the compounds in HJE, including quercetin (Q), quercetin-3-Orhamnoside (Q-3-R), quercetin-7-O-rhamnoside (Q-7-R) and quercetin-3-O-glucoside (Q-3-G) were administrated in individual, paired or mixed form of the compounds to the monolayer to evaluate their apparent permeability coefficients (Papp value). The transport of HJE was also investigated, mixture of pure components and HJE Inhibitor was added to investigate the transport mechanism of the compound mixture. The absorption of the four main ingredients in HJE was then investigated in vivo. Result: transportation of Q, Q-3-R Q-3-G but not Q-7-R through Caco-2 monolayer .. Read More»
  DOI: 10.4172/1948-593X.1000007

  Abstract PDF