Journal of AIDS & Clinical Research

Tapan N Dhole

Publications

• Research Article
  Association between Apolipoprotein B mRNA-editing Enzyme Catalytic Polypeptide-Like 3B (APOBEC3B) Deletion with HIV-1 Acquisition and AIDS among North Indian Population
  Author(s): Kavita Kakkar, Swati Sharma, Anurag Rathore, Satyendra K Singh, Nikky Nyari, Manoj Km Singh, Tapan N Dhole, Vikas Agarwal, Sayali Mukherjee and Naveen KM SrivastavaKavita Kakkar, Swati Sharma, Anurag Rathore, Satyendra K Singh, Nikky Nyari, Manoj Km Singh, Tapan N Dhole, Vikas Agarwal, Sayali Mukherjee and Naveen KM Srivastava
  
  Objective: Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-Like 3B (APOBEC3B) is involved in innate immune response, exhibiting insertion–deletion polymorphism across the world in human population. A naturally occurring 29.5 kb deletion removes complete APOBEC3B gene. Human APOBEC3B family of proteins restricts HIV- 1 replication. Very few studies have been conducted on this subject and the deductions regarding the effects of APOBEC3B deletion on HIV-1 susceptibility and pathogenesis have been largely inconsistent. Therefore, we studied the association of APOBEC3B deletion with HIV-1 in the North Indian population. Methods: Insertion (I)/Deletion (D) APOBEC3B polymorphism was analyzed using Polymerase chain reaction. Infection rates as wells as stages of HIV were compared among the three genotypes: deletion-homozygous (D/D), Insertionhomozygous (I/I) and hemizygous (.. Read More»
  DOI: 10.4172/2155-6113.1000653

  Abstract PDF