Journal of Cytology & Histology

Tarek I Abd El-Galil

Publications

• Research Article
  Effect of Methotrexate on the Jejunum of Adult Albino Rat and the Possible Protective Role of Vitamin A: Histological and Immunohistochemical Study
  Author(s): Mohamed BM Ali, Maha H Ashmawy, Ehab A A El-shaarawy, Inas A Mohamed and Tarek I Abd El-GalilMohamed BM Ali, Maha H Ashmawy, Ehab A A El-shaarawy, Inas A Mohamed and Tarek I Abd El-Galil
  
  Background: Methotrexate (MTX) is an antineoplastic drug that is widely used in the treatment of neoplasms. Patients undergoing MTX therapy have a variety of side effects affecting many important organs. Aim of the work: The aim of the present study was to detect the histological and the immunohistochemical adverse alterations that might occur in the jejunum of the adult albino rats following methotrexate therapy and to determine the possible protective role of vitamin A. Material and Methods: Seventy two adult male albino rats were divided into six equal groups. In all groups the animals were sacrificed 24 hours after the last injection. The jejunal specimens were examined using H& E and Masson’s trichrome stains and immunohistochemical examination to study the alkaline phosphatase activity using light micros.. Read More»
  DOI: 10.4172/2157-7099.1000263

  Abstract PDF