Graduate School of Medicine,
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655
Japan
Research Article
Renal Denervation Improves Cardiac Diastolic Dysfunction by Restoring Serca2a Transcription in Uninephrectomized Rats
Author(s): Hirohama D, Kawakami-Mori F, Ogura S, Mu S, Jimbo R, Uetake U, Yatomi Y, Nangaku M, Fujita T and Tatsuo ShimosawaHirohama D, Kawakami-Mori F, Ogura S, Mu S, Jimbo R, Uetake U, Yatomi Y, Nangaku M, Fujita T and Tatsuo Shimosawa
Background: The mortality and morbidity of heart failure with preserved ejection fraction has increased. Sarcoplasmic reticulum Ca2+-ATPase type 2a (SERCA2a) regulates cardiac functions, and a reduction in SERCA2a expression has been documented in left ventricular (LV) diastolic dysfunction. By contrast, SERCA2a overexpression improves LV diastolic dysfunction. Thus, transcriptional regulation of SERCA2a may be a new therapeutic target. The aim of this study was to determine whether renal denervation, a treatment for resistant hypertension, is a regulator of SERCA2a transcription in vivo.
Methods: Uninephrectomy and 6-week salt loading in three-week-old male Sprague-Dawley rats were used to devise a cardiac diastolic dysfunction model, and mechanical renal denervation was performed. The expression of SERCA2a and related molecules was evaluated.. Read More»
Journal of Hypertension: Open Access received 614 citations as per Google Scholar report