Environmental & Analytical Toxicology

Tawfek N S

Publications

• Research Article
  Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice
  Author(s): Deabes M M, Darwish H R, Abdel-Aziz K B, Farag I M, Nada SA and Tawfek N SDeabes M M, Darwish H R, Abdel-Aziz K B, Farag I M, Nada SA and Tawfek N S
  
  The effects of sub-acute exposure (7 days) to aflatoxins and the potential protective effects of Lactobacillus rhamnosus GG ATCC53013 (LGG) were studied in male Albino mice. Four experimental groups were used, each comprising 30 mice; control group, LGG-treated group (1 × 1010 CFU), AFs-treated group (0.7 mg/kg b.w.), and a group given LGG two hours before AFs intoxication. The malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase (SOD) activity were measured in liver and kidney tissues. Chromosomal aberrations in bone marrow and in spermatocytes, as well as mitotic and meiotic activities were performed to assess the genotoxicity; besides sperm parameters were evaluated. Results showed that AFs significantly elevated the tissue levels of MDA, whereas the levels of GSH as well as SOD activity were significantly decreased in liver and kidney. AFs increased signif.. Read More»
  DOI: 10.4172/2161-0525.1000132

  Abstract PDF