Journal of Clinical Case Reports

Teruki Sone

Publications

• Case Report
  Atypical Femoral Fracture in a Patient with Metastatic Breast Cancer During Denosumab Therapy
  Author(s): Kazuhiro Ohnaru, Toyohiro Kawamoto, Yutaka Yamamoto, Kensuke Tanaka, Sigeru Mitani, Toru Hasegawa, Masayuki Inubushi and Teruki SoneKazuhiro Ohnaru, Toyohiro Kawamoto, Yutaka Yamamoto, Kensuke Tanaka, Sigeru Mitani, Toru Hasegawa, Masayuki Inubushi and Teruki Sone
  
  A case of a 62-year-old woman with breast cancer who developed an atypical femoral fracture during denosumab therapy for bone metastasis is reported. About 8.5 years before the fracture, she was diagnosed with breast cancer with liver and bone metastases and started receiving chemotherapy. Three and a half years later, zoledronic acid (40 mg every 4 weeks) was added, which was continued for 2 years and 4 months. At around 1.5 years after discontinuation of zoledronic acid, bone metastasis recurred and she began treatment with denosumab at 120 mg every 4 weeks. Fifteen months after starting denosumab, she sustained a left subtrochanteric fracture. Faint hot spots in the bilateral subtrochanteric regions were found on bone scintigraphy 2 months after the start of denosumab, and the tracer accumulation was slightly increased on bone scintigraphy 1 year later. Prior to the fracture, she h.. Read More»
  DOI: 10.4172/2165-7920.1000737

  Abstract PDF