Journal of Computer Science & Systems Biology

Thirupathi M

Publications

• Research Article
  Human Rab8b Protein as a Cancer Target - An In Silico Study
  Author(s): Aboubakr HA, Lavanya SP, Thirupathi M, Rohini R, Sarita RP and Uma VAboubakr HA, Lavanya SP, Thirupathi M, Rohini R, Sarita RP and Uma V
  
  Testicular cancer develops in one or both of the testicles in young men. Rab8b is a member of the Rab small G protein family, participates in intracellular trafficking events at the site of the adherence junction dynamics in the testis. Overexpression of Rab8b and loss of functioning adherence junction accelerates the tumorigenesis in testis. In the present work, the computer aided high throughput virtual screening studies are applied to identify potent leads for human Rab8b protein. The homology model of Rab8b of 207 amino acid residues chain length was evaluated based on the crystal structure of an appropriate template, and reveals the presence of 6 α-helices and 6 β-strands. The energy of the generated model was minimized and the model was validated using ProSA PROCHECK and ERRAT server tools. The active site was identified using the computational bindin.. Read More»
  DOI: 10.4172/jcsb.1000231

  Abstract PDF