Journal of Tissue Science and Engineering

Tim JM Welting

Publications

• Review Article
  Cartilage Tissue Engineering; Lessons Learned From Periosteum
  Author(s): Peter J Emans, Marjolein MJ Caron, Lodewijk W van Rhijn, V Prasad Shastri and Tim JM WeltingPeter J Emans, Marjolein MJ Caron, Lodewijk W van Rhijn, V Prasad Shastri and Tim JM Welting
  
  Cartilage, due to its unique physiology (lack of vasculature), can be potentially repaired using tissue engineered in the laboratory, by combining cells and with a supporting scaffold. This requires a marriage between material science, cell biology, and translational medicine, a concept well established as Tissue Engineering. Over the years the in vivo and in vitro chondrogenic potential of periosteum has been recognised by many researchers and as such periosteum is explored both to repair cartilage defects directly by transplanting periosteum into the cartilage defect or by using periosteum as a cell source for cartilage engineering purposes. The initial example hereof is the first generation of Autologous Chondrocyte Transplantation. Graft hypertrophy and ossification remain the primary drawbacks of cartilage repair strategies using engineered cartilage. These drawbacks may (partial.. Read More»
  DOI: 10.4172/2157-7552.S2-002

  Abstract PDF