Journal of AIDS & Clinical Research

Timothy F Meiller

Publications

• Research Article
  Impaired Histatin-5 Levels and Salivary Antimicrobial Activity against C.albicans in HIV Infected Individuals
  Author(s): Shariq A Khan, Paul L Fidel Jr, Awdah AlThunayyan, Sharon Varlotta, Timothy F Meiller and Mary Ann Jabra-RizkShariq A Khan, Paul L Fidel Jr, Awdah AlThunayyan, Sharon Varlotta, Timothy F Meiller and Mary Ann Jabra-Rizk
  
  HIV-infected individuals constitute a population highly susceptible to opportunistic infections, particularly oral candidiasis caused by the most pathogenic human fungal species Candida albicans. Host-produced salivary antimicrobial peptides are considered to be an important part of the host innate immune system involved in protection of the oral cavity against colonization and infection by microbial species. Histatin-5 (Hst-5) specifically has exhibited potent anti-candidal properties in vitro. However, its importance in protecting the oral mucosa against candidal colonization and importantly, its contribution to the observed enhanced susceptibility of HIV-infected individuals to candidiasis has not been previously investigated. To that end, a novel immunoassay was used to demonstrate significant decrease in salivary Hst-5 levels in HIV+ individuals concomitant with enhanced candidal.. Read More»
  DOI: 10.4172/2155-6113.1000193

  Abstract PDF