Molecular Biology: Open Access

Tito N Habib

Publications

• Research Article
  Diallyl Disulphide Protects against Colon Cancer in vitro, of HT-29 Cells and in Male Rabbits of Colon Cancer Model: An Analysis of Genetic and Epigenetic Variations
  Author(s): Mohammed O Altonsy, Tito N Habib, El-Sabry A Hassanain and Gehad S MokhtarMohammed O Altonsy, Tito N Habib, El-Sabry A Hassanain and Gehad S Mokhtar
  
  Diet and dietary habits are currently accused of being among cancer causing agents. The present study was carried out in a trial to point at the beneficial anti-cancer properties of one the most Egyptian traditional food components (Garlic). We studied the anti-cancerous properties of Diallyl disulphide (DADS), a major organosulfur compound in garlic oil, on HT29 colon cancer cell line and in vivo of male rabbits (Oryctolagus cuniculus) as an animal model of colon cancer. DADS showed differential effect on the expression of a group of genes, as it down-regulated the expression of oncogenes (e.g., CTNNB1, CCDN1, BIRC5, MYC and AKT), while up-regulated the expression of tumour suppressor gene (TP53) and apoptosis regulator gene (BAX). DADS’ apoptotic effect was also seen via inducing the expression of cytochrome c and activatio.. Read More»
  DOI: 10.4172/2168-9547.1000136

  Abstract PDF