Pulmonary & Respiratory Medicine

Titto Mathew

Publications

• Research Article
  Prophylactic Administration of Curcumin Abates the Incidence of Hypobaric Hypoxia Induced Pulmonary Edema in Rats: A Molecular Approach
  Author(s): Sarada SK Sagi, Titto Mathew and Himadri PatirSarada SK Sagi, Titto Mathew and Himadri Patir
  
  Background and purpose: High Altitude Pulmonary Edema (HAPE) is a severe high altitude illness with serious pulmonary manifestations. The present study reports benefits of prophylactic administration of curcumin in prevention of hypoxia induced pulmonary edema. Experimental approach: Male Sprague Dawley rats (n=6 per group) were exposed to a stimulated hypobaric hypoxia at 7620 m for 6 h. The groups studied were (I) Normoxia, (II) Hypoxia (6 h), (III) Normoxia+curcumin (50 mg/kg BW) and (IV) Hypoxia+curcumin (50 mg/kg BW). Curcumin at 50 mg/kg BW, given orally 1 h prior to hypoxia exposure was considered from dose dependent studies as the optimum dose, due to significant reduction in the level of lung water content and lung transvascular leakage (p<0.001) as compared to control (6 h hypoxia). Biochemical analysis, vascular leakage studies, differential ex.. Read More»
  DOI: 10.4172/2161-105X.1000164

  Abstract PDF