Journal of AIDS & Clinical Research

Tomas Pumarola

Publications

• Research Article
  Impact of Fixed-Dose Combinations of Antiretrovirals on Prevalence Trends of HIV Resistance: A 7 Year Follow-Up Study
  Author(s): Angeles Jaen, Elisabeth Buira, Albert Gimenez, Tomas Pumarola, Teresa Puig, Jordi Niubo, Mariona Xercavins, Daniel Podzamczer, Bonaventura Clotet, Josep Maria Gatell and David DalmauAngeles Jaen, Elisabeth Buira, Albert Gimenez, Tomas Pumarola, Teresa Puig, Jordi Niubo, Mariona Xercavins, Daniel Podzamczer, Bonaventura Clotet, Josep Maria Gatell and David Dalmau
  
  Objectives: To determine the effectiveness of the introduction of fixed-dose combinations of antiretrovirals (FDCAs) in reducing resistance, and to describe trends of resistance-associated mutations (RAMs) in relation to drug exposure and the risk factors associated with multi-class drug resistance (MCDR) in Catalonia (Spain). Methods: Observational prospective study of HIV Resistance in Catalonia from 2002 to 2008. We included 2,718 HIV+ patients (≥16 years of age) with virological failure (Viral Load>1000 copies/ml). Differences between the Pre-FDCAs period (2002-2005) and the Post-FDCAs period (2005-2008) were assessed by multivariate logistic regressions. Prevalence of resistances and exposure to ARVs. trends were also assessed by test of trend Results: We observed a downward trend from 2002 to 2008 in all class-resistance mutations and RAMS (p<0.0001). T.. Read More»
  DOI: 10.4172/2155-6113.1000416

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