Cancer Science & Therapy

Tomoaki Kawano

Publications

• Research Article
  Relationship between Autoimmune Diseases and Imbalances in Helper/Suppressor T-cell Populations after Rituximab-containing Chemotherapyfor Non-Hodgkin Lymphoma
  Author(s): Satoko Oka, Miho Hiramatsu, Tomoaki Kawano, Naruto Matsuoka and Masaharu NohgawaSatoko Oka, Miho Hiramatsu, Tomoaki Kawano, Naruto Matsuoka and Masaharu Nohgawa
  
  Immunologic abnormalities including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) have been described in patients with non-Hodgkin lymphoma. In some cases, anti-red cell or platelet antibodies are produced by lymphoma cells. However, cases of the occurrence of autoimmune diseases without recurrence of lymphomas have been also reported. The relationship between autoimmune diseases with post-bone marrow transplantation and Hodgkin disease may be attributed to immune dysfunctions, particularly those involving T cells. This autoimmune phenomenon may be related to imbalances in helper/suppressor T-cell populations. Imbalances in helper and suppressor T-cell populations have been reported after R-CHOP chemotherapy, and the recovery of serum IgG and CD4+ counts was observed more than 2 years after R-CHOP therapy in patients with B-cell lymphoma. In this report,.. Read More»
  DOI: 10.4172/1948-5956.1000482

  Abstract PDF