Neurological Disorders

Torres-Merino S

Publications

• Research Article
  Association of a Functional Inducible Nitric Oxide Synthase Promoter Variant with Susceptibility to Infantile Cerebral Palsy
  Author(s): Torres-Merino S, Moreno-Sandoval HN, del Rocio Thompson-Bonilla M, Gonzalez-Barrios JA, Leon-Chavez BA and Martinez-Fong DTorres-Merino S, Moreno-Sandoval HN, del Rocio Thompson-Bonilla M, Gonzalez-Barrios JA, Leon-Chavez BA and Martinez-Fong D
  
  Background: Recently it has been shown an increase in the interleukin 1 beta and nitrite levels in cerebrospinal fluid as a primary response of the immature brain to oxygen deprivation in newborns that suffered perinatal asphyxia, 30% to 40% of these patients later develop neurological abnormalities incluiding cerebral palsy. Formerly was shown that an increased enzyme activity of NOS2 is responsible for the increase in nitrite levels in cerebrospinal fluid. The NOS2A gene has a polymorphic microsatellite (CCTTT)n located at -2.6 Kb from the gene promoter. The expansion of this microsatellite to 13 or 14 repeats increases transcription of the NOS2A gene and triples the nitric oxide level under hypoglycemia and hypoxia conditions. The study aim was shown that the expansion of -2.6 Kb CCTTT microsatellite in the NOS2 gene promoter, constitutes a risk factor for developing cerebral palsy.. Read More»
  DOI: 10.4172/2329-6895.1000248

  Abstract PDF