Journal of Clinical Case Reports

Tsumura H

Publications

• Case Report
  Concurrent Occurrence of Hemophagocytic Syndrome and Myelofibrosisin a Case of SLE
  Author(s): Kondo M, Murakawa Y, Sumita Y, Moriyama M, Honda M, Yamaguchi T, Tsumura H, Kumakura S and Yamaguchi SKondo M, Murakawa Y, Sumita Y, Moriyama M, Honda M, Yamaguchi T, Tsumura H, Kumakura S and Yamaguchi S
  
  We experienced a case of Systemic Lupus Erythematosus (SLE) with myelofibrosis and hemophagocytosis. Recently, it has become clear that hemophagocytosis can occur with autoimmune diseases, including SLE. By contrast, myelofibrosis is a rare complication of SLE, and only ten cases have been reported. The mechanism by which myelofibrosis complicates SLE remains unknown. There are several theories: myelofibrosis may result from microvasculitis in the marrow or the unusual release of cytokines. Myelofibrosis accompanying SLE appears to be reversible with immunosuppressive therapy, although primary myelofibrosis is not. This suggests that the pathogenesis of myelofibrosis with SLE is quite different from that of primary myelofibrosis. This is the first report of SLE accompanied by myelofibrosis and hemophagocytosis. In our cases, serum TGF.. Read More»
  DOI: 10.4172/2165-7920.1000553

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