Cancer Science & Therapy

Tursun Alkam

Publications

• Research Article
  Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling
  Author(s): Zohra Tumur, Carlos Guerra, Peter Yanni, Ahmad Eltejaye, Christi Waer, Tursun Alkam and Bradley S HensonZohra Tumur, Carlos Guerra, Peter Yanni, Ahmad Eltejaye, Christi Waer, Tursun Alkam and Bradley S Henson
  
  Objective: Active components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. Rosmarinic acid (RA), a phenolic compound in various herbal plants, is well-recognized for its anti-oxidant, anti-inflammatory, anti-proliferative properties in a variety of cell types. In this report, we describe a novel role for RA as an inhibitor of epidermal growth factor (EGF) stimulated signaling in HNSCC and propose a cellular reactive oxygen species (ROS)-mediated mechanism for the observed effects. Methods: Cellular growth, migration and reactive oxygen species (ROS) profiles were examined in RA-treated and untreated HNSCC cell lines (UM- SCC-6 and UM-SCC-10B) using the WST-1 viability assay, established in vitro migration assays, and the CM-H2DCFDA ROS assay, respect.. Read More»
  DOI: 10.4172/1948-5956.1000376

  Abstract PDF