Journal of AIDS & Clinical Research

Ulrich Hengge

Publications

• Research Article
  Co-Receptor Tropism Determined by Genotypic Assay in HIV-1 Circulating in Cuba
  Author(s): Vivian Kourí, Yoan Alemán, Dianne Díaz, Lissette Pérez, Celia M Limia, Yudira Soto, Yenisleidys Martínez, Yoanna Baños, Yaniris Caturla, Jorge Campos, Lilia M Ortega, Jorge Pérez and Ulrich HenggeVivian Kourí, Yoan Alemán, Dianne Díaz, Lissette Pérez, Celia M Limia, Yudira Soto, Yenisleidys Martínez, Yoanna Baños, Yaniris Caturla, Jorge Campos, Lilia M Ortega, Jorge Pérez and Ulrich Hengge
  
  Introduction: R5-tropic viruses predominated at the time of initial HIV-1 infection and a switch to X4-tropic occurs in about 50% of patients in late-stage disease. Objective: To associate different variants of Cuban HIV-1 with the co-receptor use, and the implication for the use of co-receptor inhibitors. Methodology: Viral HIV-1 subtype was determined in 42 Cuban individuals using COMET V.2, Rega subtyping toolV.3 algorithms and phylogenetic analysis. Co-receptor tropism was predicted using the geno2pheno [co-receptor] algorithm. Additionally, all V3 loop HIV-1 Cuban sequences deposited previously at Los Alamos database were also analyzed for comparison of subtype and co-receptor tropism. Results: The most frequent subtypes detected were CRF20–23–24_BG (35.7%), subtypes B (33.3%) and CRF19_ cpx (14.3%) when pol and V3 regions were analyzed. Overal.. Read More»
  DOI: 10.4172/2155-6113.1000592

  Abstract PDF