Pulmonary & Respiratory Medicine

Uwe Christians

Publications

• Research Article
  Exhaled Breath Condensate Nitrate Levels are Inversely Associated with the Body Mass Index of Patients without Respiratory Disease
  Author(s): Ana Fernandez-Bustamante, Tamas Seres, Amanda Agazio, Alexander T. Pennington, Uwe Christians, Jelena Klawitter and John E. RepineAna Fernandez-Bustamante, Tamas Seres, Amanda Agazio, Alexander T. Pennington, Uwe Christians, Jelena Klawitter and John E. Repine
  
  Background: Repeated observations suggest that the incidence and/or severity of the Acute Respiratory Distress Syndrome (ARDS) is lower in mildly obese humans compared to lean subjects, phenomenon called the Obesity-ARDS Paradox. A reduced lung nitrosative stress could contribute to this unexplained protection. We measured levels of nitrate, the most oxidized nitric oxide (NO) metabolite, and other related metabolites in the exhaled breath condensate (EBC) of obese (composed of both overweight or mildly obese) and normal weight patients. Methods: We studied patients without respiratory disease immediately after starting mechanical ventilation for elective surgery. We performed targeted metabolomics analyses of EBC and blood samples. We measured concentrations of arginine, asymmetrical dimethylarginine (ADMA), symmetrical dimethylarginine (SDMA), nitrite, and nitrate and then.. Read More»
  DOI: 10.4172/2161-105X.1000243

  Abstract PDF