Journal of Bioprocessing & Biotechniques

Valerie Smith

Publications

• Research Article
  The Effect of Novel Rhenium Compounds on Lymphosarcoma, PC-3 Prostate and Myeloid Leukemia Cancer Cell Lines and an Investigation on the DNA Binding Properties of One of these Compounds through Electronic Spectroscopy
  Author(s): Carl Parson, Valerie Smith, Christopher Krauss, Hirendra N Banerjee, Christopher Reilly, Jeanette A Krause, James M Wachira, Dipak Giri, Angela Winstead and Santosh K MandalCarl Parson, Valerie Smith, Christopher Krauss, Hirendra N Banerjee, Christopher Reilly, Jeanette A Krause, James M Wachira, Dipak Giri, Angela Winstead and Santosh K Mandal
  
  Despite the tremendous success of cisplatin and other platinum-based anticancer drugs, severe toxicity and resistance to tumors limit their applications. It is believed that the coordination of the metal to DNA bases causes the ruptures of the cancer as well as normal cells. A search for anticancer drugs with different modes of action resulted in the synthesis of variety of novel compounds. Recently we synthesized a series of novel rhenium pentylcarbonato compounds (PC1-PC6). The rhenium atom in each compound is coordinated to a planar heterocyclic aromatic ligand, thereby forcing each compound to intercalate between the DNA bases. The UV absorption titrations of PC6 with DNA shows hypochromic effect with concomitant bathochromic shift of the charge transfer band at 290 nm. These results suggest that the compound PC6 binds to DNA through intercalation. It is likely that many of the ot.. Read More»
  DOI: 10.4172/2155-9821.1000141

  Abstract PDF