Journal of Metabolic Syndrome

Valery N Shipilov

Publications

• Research Article
  The Brain Adenylyl Cyclase Signaling System and Cognitive Functions in Rats with Neonatal Diabetes under the Influence of Intranasal Serotonin
  Author(s): Alexander O Shpakov, Kira V Derkach, Oksana V Chistyakova, Ivan B Sukhov, Valery N Shipilov and Vera M BondarevaAlexander O Shpakov, Kira V Derkach, Oksana V Chistyakova, Ivan B Sukhov, Valery N Shipilov and Vera M Bondareva
  
  Type 2 diabetes mellitus is often associated with the neurodegenerative changes, and this is regarded as being the cause of cognitive deficit and other brain dysfunctions. The data obtained by us and the other authors showed that alterations in the brain signaling systems regulated by different hormones and neurotransmitters contribute to triggering and development of neurodegenerative processes in diabetes. However, the activity of brain adenylyl cyclase system and the cognitive functions, their interrelation, and the influence of intranasal serotonin on them in type 2 diabetes are poorly understood yet. We investigated the hormonal sensitivity of adenylyl cyclase system in the brain of female rats with the neonatal model of type 2 diabetes and the influence of 8-weeks treatment with intranasal serotonin (20 μ g/rat daily) on the brain adenylyl cyclase system and cognition in di.. Read More»
  DOI: 10.4172/2167-0943.1000104

  Abstract PDF