Journal of Bioanalysis & Biomedicine

Veerendra K. Nanjwade

Publications

• Research Article
  Formulation and Characterization of Hydralazine Hydrochloride Biodegraded Microspheres for Intramuscular Administration
  Author(s): Basavraj K. Nanjwade, Hiren M. Bechra, Veerendra K. Nanjwade, Ganesh K. Derkar and F. V. ManviBasavraj K. Nanjwade, Hiren M. Bechra, Veerendra K. Nanjwade, Ganesh K. Derkar and F. V. Manvi
  
  Objective: To prepare and characterize Albumin microspheres of hydralazine hydrochloride for the treatment of hypertension. Methods: Albumin microspheres of antihypertensive drug hydralazine hydrochloride were prepared by emulsion cross-linking method by using glutaraldehyde as cross-linking agent. Drug and polymer compatibility was determined by Fourier-Transform Infrared spectroscopy. To determine the effect of polymer concentration and amount of glutaraldehyde, formulations were characterized for their entrapment efficiency, particle size, surface morphology and release behavior. In vivo study was carried out on hypertensive wistar rats. Key findings: Maximum percentage entrapment efficiency (%EE) was found to be 68.20±1.03 %. Laser particle size analyzer confirmed mean particle size in th.. Read More»
  DOI: 10.4172/1948-593X.1000040

  Abstract PDF